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Patients on tirzepatide lost about 50 pounds compared to 33 pounds for those on semaglutide

Semaglutides SUSTAIN-6 trial demonstrated a significant reduction in major adverse cardiovascular events in adults with type 2 diabetes, along with improvements in body weight and HbA1c (NCBI Bookshelf)

The rationale for the combination is based on extrapolation from the established anti-nausea evidence, the known neurotransmitter mechanisms, and anecdotal reports from clinicians and patients who use the compounded formulation

Additional useful items include a small notebook to track injection dates during travel, especially if you're in a different time zone or managing multiple time zones during your trip

The weight loss dose is 2.4 mg, more than double

In the SURPASS-2 head-to-head trial, rates were comparable