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Following AAV-shRNA delivery, mice were fed a MASH-inducing diet rich in fat, cholesterol and fructose, which better recapitulates human liver inflammatory pathology 34 (Fig

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From these studies, it is unclear whether, ultimately, it is the accumulation of oxidized phospholipids that is essential for the nuclear transmigration of AIF or whether hydrogen peroxide stimulates apoptogen release by other mechanisms

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