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Taking cues from these approaches, our group designed a biotin linker consisting of three parts: 1) a biotin moiety, 2) a Boc-derivative cleavable by TFA, and 3) an alkyne group for bioorthogonal ligation with azide-functionalized sulfenic acid probes

It is present in nearly all cells of the human body and plays crucial roles in numerous processes

Kyn, 3OHK and 3OHKG are found prominently in young lenses (102), but decline at a rate of ~12% per decade, with kyn and 3OHK being nearly undetectable in 80 year old lenses (110)

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A recent trial of lutein supplements in patients with AMD showed that both lutein alone and lutein combined with vitamins, minerals and antioxidants improved both objective and subjective visual function

in its active form (thiamine diphosphate), it is an essential cofactor for enzymes in glucose and amino acid catabolism, helping convert nutrients into ATP and supporting normal neuronal function