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one such mechanism includes increased intestinal permeability or the leaky gut, which is very prevalent in the case of PD

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Acknowledgements Editorial support was provided by Richard Ogilvy-Stewart of Apollo, OPEN Health Communications, and funded by Novo Nordisk A/S, in accordance with Good Publication Practice guidelines (www.ismpp.org/gpp-2022)

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This review systematically elucidates how the microbiota-ENS axis modulates the function of the ENS through multilevel signaling transduction involving microbial metabolites (SCFAs, BAs), intestinal hormones (GLP-1, CCK, leptin, ghrelin), and neurotransmitters (5-HT, Ach, VIP, NO, GABA), thereby regulating gastrointestinal motility

In the case of the fusobacterium Propionigenium modestum it drives the counter-rotation of subunits a and c of the F O motor of ATP synthase