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A study of the cerebral volume and induced stroke following middle cerebral artery occlusion in mice showed that HHcy was associated with increased oxidative damage and larger ischemic lesion [1719]
doi:10.1159/000094268
207,208 CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP3A4 can catalyze hydroxylation on both the 1 and 2 positions
This inadequate antioxidant capacity renders beta cells incapable of counteracting oxidative damage
added another option to the previously mentioned strategy by engineering an OV that could secrete IL-12p70 in addition to the PD-L1-blocking antibody to promote the anti-tumor efficacy of CAR-T cell therapy for head and neck cancer
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