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Cells treated with test compounds were washed with PBS and incubated with 10 M 2,7-dichlorofluorescein diacetate (DCFH-DA) at 37 C for 30 min, followed by washing with PBS, digestion with trypsin, and collection

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While the transappendageal pathway, which utilizes appendages such as hair follicles, sweat ducts, and sebaceous glands, constitutes only about 0.1% of the skin surface area (though this percentage may be higher in specific regions such as the forehead) [22], its contribution to percutaneous transport is generally considered secondary

Reduced glutathione is generally considered safe for skin whitening when used under medical supervision

Due to the Mayo clinical studies in the 1980s, many orthodox, mainstream clinicians have a prejudice against vitamin C therapy

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