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This showed the same trend as in the comparison between the control and MDD groups (Figure 6A)

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However, -KG supplementation downregulated the expression levels of H3K9me3 and H3K27me3 (Fig

doi: 10.1016/j.chest.2021.07.2170

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This finding suggests crosstalk between mechanical stress, via specific ion channels, and intracellular oxidative stress pathways, collectively influencing chondrocyte fate