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Competition for Vitamin B12 by intestinal parasites or bacteria
In Belgium, the prevalence of analgesic nephropathy was 18%, whereas the European Dialysis and Transport Association registered a prevalence of 12% (Elseviers & De Broe, 1988)

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It has also been shown in research to activate the CREB/PGC-1-alpha pathway, which plays a role in suppressing neuroinflammation by reducing pro-inflammatory cytokines and promoting anti-inflammatory mediators
