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The formulation and dosage regimens of B12 used to treat Vitamin B12 deficiency vary widely depending on the aetiology of the deficiency as well as region of medical practice (Table 2)

& Ruoslahti, E

& Penner, R

however, the upregulated genes in malignant cells were enriched in cellular senescence, RNA degradation, thermogenesis, spliceosome, and ubiquitin-mediated proteolysis, suggesting that in malignant cells, the activities of RNA degradation and splicing are significantly increased, and ubiquitin-mediated proteolysis is increased, which reflects the cellular response to malignant transformation