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The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications

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IGF1 can reduce blood glucose levels and has been used to treat patients with type 1 and 2 diabetes This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF