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At the time, the FDA presented a lot of adverse event data that showed there was a risk of immunogenicity immune reactions and that raised some red flags for the committee, said Gupta, an adjunct assistant professor of anesthesiology at the Johns Hopkins University School of Medicine

As a research peptide, peptide DSIP continues to offer valuable opportunities for advancing scientific understanding of sleep physiology, stress adaptation, and neurological function

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Adverse reactions that have been identified during postapproval use of BOTOX are discussed in greater detail in Postmarketing Experience (Section 6.3 of the Prescribing Information)

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