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Trempe JF, Sauve V, Grenier K, Seirafi M, Tang MY, Menade M, Al-Abdul-Wahid S, Krett J, Wong K, Kozlov G, Nagar B, Fon EA, Gehring K (2013) Structure of Parkin reveals mechanisms for ubiquitin ligase activation

Jiayi Jin was involved in writing the first draft as well as creating all the illustrations and tables

In HIV, oxidation of tryptophan along the kynurenine pathway, because of chronic inflammation, is considered to be the main cause of tryptophan depletion and hence niacin deficiency

The authors declare that they have no conflicts of interest

Patients currently undergoing chemotherapy treatment for cancer should wait until treatments are completed before opting for glutathione IV therapy, as it could affect chemos ability to treat tumors

When pigment particles enter the trabecular meshwork endothelial cells, they can gradually lead to pigment overload and death of the trabecular meshwork cells