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91,212 These agents mediate by disrupting the CD44-HA attachment as well as inhibiting the expression of the CD44 and downstream effectors like NF-KB, JNK

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Based on the IAP activity influenced by pH, the IAP activity was increased by increasing the intestinal pH in vivo

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Besides, clinical outcomes have often been less robust than preclinical data suggested, partly due to the complexity of AMLs genetic and epigenetic heterogeneity, the limitations of model systems, and intrinsic resistance mechanisms