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However, the so-called heme-anemic proteins with an incomplete heme saturation naturally occur outside the circulatory system [150]

MetS patients treated with amlodipine, chlorthalidone, or lisinopril had comparable risks of developing T2DM and vascular events

doi: 10.3390/biomedicines10123067 76

Dysfunction in the ENS has been linked to a range of gastrointestinal disorders, including irritable bowel syndrome, gastroparesis, and inflammatory bowel diseases

Several treatments that can therapeutically target these pathways have been tested in preliminary clinical trials