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Methionine is the precursor of cysteine in TR/GR-null livers As TR/GR-null hepatocytes required GSH synthesis for DNA replication but could not reduce GSSG, we inferred that cytosolic disulfide-reducing power came from de novo synthesis of GSH used in single-turnover reactions

5.1.3 Tocopherols (vitamin E) Tocopherols are lipid-soluble antioxidants essential for membrane integrity synthesized in the plastid envelope from homogentisic acid and isopentenyl diphosphate

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Pyridoxal phosphate (P5P) is B6 (Al-Sadeq & Nasrallah, 2020)

Smart nanocarriers not only improve targeted drug accumulation at lesion sites but also enable co-delivery and temporally controlled release of multiple therapeutics, significantly enhancing efficacy while reducing systemic toxicity [77]