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In a double-blind, multicenter trial of valproate in elderly patients with dementia (mean age was 83 years old), doses were increased by 125 mg/day to a target dose of 20 mg/kg/day
Because dietary carnitine deficiency in infancy is considered to cause smooth muscle dysmotility of the gastrointestinal tract similarly to that in their skeletal muscles in the extremities, carnitine deficiency in hemodialysis patients may be one cause of gastrointestinal discomfort and dysfunctions [3]
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