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The randomized, double-blind, placebo-controlled study tested various doses of Danuglipron against a placebo over 16 weeks

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Inhibitors of polyamine metabolism, such as alpha-difluoromethylornithine, lead to a reduction in polyamine production, and a disruption of the cell cycle and DNA synthesis in cancer cells [60,61]

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Oncol Lett 29:175

Furthermore, correlation analysis between molecular biomarkers on both measured gene and protein levels against clinical outcomes, specifically intraocular pressure (IOP) reduction across different animals within the same treatment group was done to examine how the molecular expression patterns align with physiological responses