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The maintenance dose may be increased to 300 mg monthly for patients who tolerate the 100-mg dose and do not demonstrate a satisfactory clinical response [23]
4 In addition, safety concerns around electrical stimulation therapy, especially with long-term use, have not been adequately addressed

A J Physiol

(2015) and Campos et al

As little as one drink per day has been shown to raise the risk of GI bleeding by 37% among NSAID users (292)
