incretin mimetic agents glp 1 receptor agonists Incretin-Based Therapies Through the Decades: Molecular Innovations and Clinical Impact The Influence of Glucagon-like Peptide-1
Description
Clinical trials have shown improvements in A1C, which is a blood test used to measure average blood sugar levels over time
Researchers can distinguish absorption-limited from clearance-limited kinetics, examine metabolite generation and activity, and assess variability introduced by gastrointestinal physiology
Not just weight loss, but an improvement in the underlying metabolic dysfunctions driving these conditions
Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A, SURMOUNT-1 Investigators (2022) Tirzepatide once weekly for the treatment of obesity
Furthermore, GLP-1 decreases glucagon secretion from pancreatic cells and has also extrapancreatic influences as a direct suppressive effect on appetite centers and a slowing of gastric emptying increasing the feeling of satiety
Research shows that Wegovy may be the better choice for weight loss because it goes up to 2.4 mg weekly as an injectable and up to 25 mg as a pill
