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After all, activation of AT1R not only promotes endothelial dysfunction (Skultetyova et al., 2007) and vasoconstriction (possibly causing CBF reduction) but also increases peripheral and central sympathetic nervous system activity, BBB disruption (Mowry et al., 2021), oxidative stress and inflammatory activity (Wang et al., 2012), plausibly including CNS inflammation (Cosarderelioglu et al., 2020

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GSH depletion in RPE cells increased the number of red puncta, indicating an increase in autophagic flux (Fig