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Small real-world series also suggest that reduced-frequency dosing can hold a plateau

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These findings establish the mechanistic basis for the compound and provide proof of concept for its metabolic effects

In addition, heparanase expression is high, principally in the glomerulus, 2448 h after LPS treatment, which leads to the glomerular loss of HS and glycosaminoglycans, and is associated with high blood urea nitrogen (BUN), high urinary albumin/creatinine ratio, and glomerular injury (93, 94)

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