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In clinical settings, intravenous choline supplementation is sometimes used for patients with critical illness, liver disease, or total parenteral nutrition (TPN) to prevent or correct deficiency-related complications

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( f ) Quantification of H2AX foci in cells transduced with shRNA targeting IDH1 alone or combined with overexpression of wildtype IDH1 (wtIDH1 OE) (n = 3 technical replicates from 3 independent experiments in each cell line)

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