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Besides the presently reported decreased PST activities, blood hyperserotonemia was also reported to result from increased SERT activity due: (i) to the rare Ala56 ASD-associated gain-of-function mutation in the SLC6A4 gene found in some ASD patients 13 which altered the communication and social domains in knock-in mice 85 or (ii) to a variant in the promoter of the ITGB3 gene 86 which encodes the -chain of the platelet integrin IIb 3 known to interact physically with SERT to promote its externalization and transport activity 87

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10.22074/cellj.2016.4867 94 GiannenasI.SidiropoulouE.BonosE.ChristakiE.Florou-PaneriP

Reference CJC-1295 DAC Dosing Protocol According to available clinical data, CJC-1295 DAC has been administered effectively in doses ranging between 30-60mcg per kilogram of body weight per week [12]

Certificates of analysis support batch review by giving the procurement team a document tied to a specific lot

Clin Exp Rheumatol (2000) 18(6):6918