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A second study showed that vitamin B6 improved extracellular matrix metabolism and reduced chondrocyte apoptosis, which are also known to play a role in OA pathogenesis [73]

Two promising clinical trials showed positive outcomes in improving ASD symptomatology with minimal adverse effects

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These canonical functions positioned DHODH primarily as a metabolic enzyme critical for nucleotide biosynthesis and cellular proliferation, before its more recent identification as a mitochondria-specific ferroptosis suppressor in select cancer contexts

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