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Weakened tight junction increases the intestinal barrier permeability, which enables leaky gut effect, leading to increased levels of anti- Ruminococcus gnavus antibodies (anti-RG) that act on Ruminococcus gnavus (RG) antigens and worsen kidney damage in lupus patients (82)

Warnings: Patients with early Leber's disease (hereditary optic nerve atrophy) may experience severe and rapid optic atrophy when treated with vitamin B12. Additionally, treating severe megaloblastic anemia with vitamin B12 can lead to fatal hypokalemia due to increased erythrocyte potassium requirements

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Never use same needle and syringe twice, and dispose of all components as per local regulations

Proteasomes play a crucial role in the degradation of oxidized and ubiquitinated proteins, thus maintaining protein homeostasis and ensuring an adequate cellular stress response