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Description
Data availability The datasets generated and analyzed during this study are included in the Supplementary files

In CRC, claudins (CLDNs) play an important role in the neoplastic transformation of premalignant epithelium tissue as demonstrated in APC min mice, where the overexpression of Cldn1 induced tumour growth and progression (119)

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Upregulation of HLADR, intercellular adhesion molecule-1 and E-selectin activates CD2+, CD3+, CD5+, CLA+, CD45RO, HLA-DR, CD25 (IL-2 receptor) and CD27 expressing T cells [2]

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