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Antioxidants (Basel) 10:1269

Structure-activity relationship studies have highlighted that the two phenyl rings connected by a C-7 linker with keto-enol functionality are crucial for curcumins biological activity (87)

Leichtle, A., Lai, Y., Wollenberg, B., Wasserman, S

Preoperative data comprised the distance of the tumor from the anal verge, hemoglobin level, albumin level, presence of bowel obstruction, neoadjuvant therapy (chemotherapy, targeted therapy, immunotherapy, and radiotherapy), and neoadjuvant radiotherapy status

These factors collectively worsen mitochondrial dysfunction and impair effective ER-mitochondrial interaction in AD

W., Foster, R