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3 The UK National Institute for Health and Care Excellence (NICE) states that a cut-off of 200 ng/l identifies 97% of people with B12 deficiency, and a level below 100 ng/l is usually accompanied by metabolic or clinical evidence of B12 deficiency

As a result, laboratories gain clearer insights into peptide-based cellular regulation
reported that compared with control mice, inducible Slc39a8 knockout (Slc39a8-iKO) and liver-specific Slc39a8 knockout (Slc39a8-LSKO) mice had decreased Mn levels in the blood and in multiple organs but no changes in Zn or Fe levels 16

doi: 10.3390/metabo12080720 21 BonnetU.BingmannD.WiemannM

In: Handbook of evidence-based practices in autism spectrum disorder

The benefit comes from replacing whats missing, not from extra B12 on top of normal levels
