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sCT when bound to AMYRs induce a CT-like receptor conformation 15 , while P32Y substitutions of CT analogues are also detrimental to affinity and potency at AMYRs 18,19

We tested the modified Dihexa against 200 M neomycin and observed no protection, suggesting that the current form of Dihexa has a high specificity for providing protection, likely via its specific interaction with native HGF (Figure 7)

This side effect is reversible, but can require 3-6+ months of recovery

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Clinical background variables Clinical data were collected from an electronic patient record, including information (i) before delivery (maternal glucocorticoid administration, chorioamnionitis, pregnancy-induced hypertension, multiple births, intravenous tocolysis, maternal hospital stay until delivery, and delivery mode), (ii) after birth (gestational age, sex, Apgar scores, intrauterine growth restriction, and requirement for invasive/non-invasive mechanical ventilation), and (iii) at the time of the study (postnatal age, feeding mode, clinical record of postnatal glucocorticoid administration, requirement for non-invasive mechanical ventilation using a nasal continuous positive airway pressure device, and invasive blood sampling in the morning of the study)

Peptides are short chains of amino acids, the fundamental components that construct proteins