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For millions of people living with hearing loss whether mild, severe, or profound this is an everyday reality

In the case of lipid disorders, intensive lipid-lowering treatment is currently recommended (and not just intensive statin treatment, as it has been for years) in order to achieve in our patients as low concentrations of low density lipoprotein (LDL) cholesterol as possible, according to the rule of the lower the better, but also to do it as soon as possible (the earlier the better) and maintain it as long as possible (the longer the better), as this gives us a chance to reduce the risk of cardiovascular events even in every other patient (5055%) [6, 7]

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A well-received competition model has been proposed 15,40 : transcription of lipid catabolism genes is repressed by bHLH-like transcription factors under well-fed conditions, and during starvation, the downregulation of transcriptional repressors allows accessibility of transcriptional activators to the promoter regions of lipid catabolism genes, thereby activating fat utilization

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