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Functionally, MCS represents an adaptive attempt to preserve core cell functionsincluding proliferation, differentiation, migration, secretion, neuronal signaling, and muscle contractionand, under pathological conditions, to sustain pro-inflammatory activity [187,190]

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The ensuing OxS has been implicated in damage to neuronal processes in vitro [148], consistent with the reduction of dendritic spines observed in schizophrenia [149, 150]

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4 Measurement of liver injury in liver and/or gut Aldh2 KO post chronic-plus-binge ethanol feeding