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A decrease in astrocytic presence in the brain reduces homeostatic support of nervous tissue, while decreased astrocytic synaptic coverage affects synaptic transmission and plasticity, which are translated into depressive symptoms and behaviors 143

Metabolic dysfunctions, including accumulation of lipids like polyunsaturated fatty acids and cholesterol, are involved in the misfolding and aggregation of alpha-synuclein [194]

The identification of two forms of MAO, known as MAOA and MAOB, and their respective selective inhibitors has contributed to a better understanding of their physiological roles, regulation of neurotransmitter metabolism and the mechanism of the 'cheese reaction', and has led to the development of selective inhibitors that avoid this side effect

On the flip side, boosting glutathione levels helps support better sleep

Yang, O

After 2.5 h of induction, l-glutamate, glycine and l-cysteine were added into the bioreactor to concentrations of 25 mM