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Although members of the CGFS (class II) sub-family are sometimes referred to as monothiol GRX, in at least some cases catalytic activity involves formation of an intramolecular disulfide bond with a second cysteine located distally from the GRX active site motif

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4 (12), e1000300

CR-activated cell cycle periodic genes in our study are directly or indirectly involved in tumorigenesis pathways, drive cancer cell proliferation and aggressiveness (RRM2, ACSL3, RBBP8, KMO, FKBP5), drug resistance (ABCC5) and modulate chemosensitivity (FKBP5) (references in Supplementary Table S2A)

Nox inhibitors & therapies: rational design of peptidic and small molecule inhibitors

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