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Enhancement of S -adenosylmethionine-dependent methylation by integrating methanol metabolism with 5-Methyl-tetrahydrofolate formation in Escherichia coli

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Research on CRC metastasis demonstrates significantly elevated SREBP2 expression in liver metastases compared to primary tumorsa phenomenon not observed in brain or lymph node metastasesindicating pathway-specific activation of cholesterol synthesis in hepatic metastasis