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Hence PKC is less likely to result in offtarget immunosuppression.133 As a result, PKC , is highly studied as a potential therapeutic target.9 The most advanced PKC inhibitor to be developed is sotrastaurin (AEB071), which is currently undergoing clinical trials for the treatment of psoriasis and organ transplantation.134, 135, 136, 137, 138 Another promising pharmaceutical PKC inhibitor is compound 27, for which oral administration in mice led to a decreased IL2 response.139 Furthermore, similar compounds of PKC inhibitors developed by the same group were developed and tested in in vivo mouse models of colitis and multiple sclerosis and the mice treated with the PKC inhibitors showed improved general wellbeing and reduced disease severity.140 Undoubtedly, these findings highlight the importance and great potential for development of small molecule inhibitors of PKCs in treating immunemediated diseases

The baseline MRI should be obtained when the patient is aged 46 months