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Limitations in biomarkers, imaging, and trial design illustrate the gap between mechanistic insight and clinical application

10.1186/s12951-025-03415-w [DOI] [PMC free article] [PubMed] [Google Scholar] Lu S

The peptide can influence gene expression, promoting a youthful phenotype by activating reparative processes in skin cells and reducing oxidative damage

Oral Bioavailability and Protease Resistance Unlike true peptides, Dihexa resists gastrointestinal peptidase degradation due to its peptidomimetic structure

The Lancet Neurology In the LEGATO-HD Phase 2 double-blind, placebo-controlled trial of laquinimod in patients with HD, laquinimod did not show a significant effect on motor symptoms assessed by the UHDRS-TMS but significantly reduced caudate volume loss compared with placebo at week 52

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