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This hypothesis was investigated in the Fabry kidney organoid model

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p=0.24), and heterogeneity was negligible ( I 2 =0%) (Fig

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When the transport of dopamine into synaptic vesicles is obstructed or VMAT2 is inhibited by drugs such as tetrabenazine and reserpine, excessive dopamine can accumulate in the cytoplasm, leading to the auto-oxidation of dopamine and the formation of harmful by-products, eventually leading to neurodegeneration