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For leaders, the peptide boom comes down to two things: agency and leverage

Rebouche CJ, Seim H (1998)

Rodents, such as mice and rats, are the most commonly used animal species (54%) in IVD studies (Poletto et al., 2023)

Reversal of Bortezomib-Induced neurotoxicity by suvecaltamide, a selective T-Type Ca-Channel modulator, in preclinical models

The 2 CT method was used for the relative quantification of the target to the reference ( -actin was selected as the housekeeping gene due to its consistent expression under our experimental conditions, as previously validated in HepG2 cells treated with pharmacologic agents ( Housekeeping genes are favored for two reasons: they encode proteins that undergo stabilizing selection to maintain metabolic function, and they exhibit sufficient variability to detect a range of variants in the isolate collection

There have been efforts to develop more soluble linkers for the maytansinoids
