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It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway

[DOI] [PMC free article] [PubMed] [Google Scholar] Williams R.T

Quick Take 1: Vegans and vegetarians can get B12 from plant sources, but have to consume a lot of these foods daily, including organically grown cress, shitake mushrooms, nori seaweed, and fermented vegetables

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