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The exact mechanism by which Botox works is not fully understood, but it is believed to inhibit the release of pain-causing neurotransmitters and block nerve signals that contribute to headaches

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[DOI] [Google Scholar] 56.Wong K.H., Sabaratnam V., Abdullah N., Kuppusamy U.R., Naidu M

A total of 50 participants (men and women, 3560 years of age) with dry skin, skin moisture content of 49% or less, or crows feet greater than grade 3 were tested for 12 weeks in this double-blind, randomized, parallel, placebo-controlled study (equal numbers of subjects were in the APCP or placebo groups)