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Several studies have tested GLP-1 and combination medications for people with MASLD who have not yet progressed to MASH and have little or no fibrosis Another dual GLP-1/glucagon agonist, pemvidutide, reduced liver fat content by up to 69% in people with MASLD and no significant fibrosis, compared with 4% in the placebo group, and more than half achieved normal liver fat levels

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In obesity and T2D, the depletion of beneficial taxa allows the expansion of potentially harmful, endotoxin-producing bacteria beyond physiological equilibrium (9092)

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