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Temperature Constraints As ectothermic organisms, zebrafish depend on external temperatures, typically maintained at 2829 C during experiments

This difference in succinate levels between seals and humans experiencing hypoxia is consistent with the human cells, but not the seal cells, needing to rely on glycolysis during hypoxia, as seals may use succinate as their energetic substrate instead

The alteration of the balance between the ROS amount and the antioxidant system in favour of the former leads to oxidative stress

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Remarkably, cell lines with missense TP53 mutations, which typically accumulate mut-p53 protein, are most sensitive to knockdown of SLC7A11 than any other antioxidative stress gene (Fig

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