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Oxidative stress may also indirectly contribute to deamidation through its impact on cellular processes
Srour B, Chazelas E, Fezeu LK, et al
There is a close relationship between IR/diabetes and MAFLD, the mechanisms by which IR promotes MAFLD include changes in rates of adipose tissue lipolysis and de novo lipogenesis, impaired mitochondrial fatty acid -oxidation (FAO), changes in fat distribution, and alterations in levels of adipokines and cytokines (Tilg et al., 2017
Interestingly, nitric oxide inhibits mitochondrial respiration by reacting with either the reduced or the oxidized binuclear site of cytochrome c oxidase, leading to ATP depletion
J Cereb Blood Flow Metab 36: 5571
