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In addition, l-carnitine may reduce the oxidative stress of skeletal muscles caused by intermittent hypoxia, thereby improving the strength, regeneration, and recovery of fatigue of muscles [32]

Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients

Another important mechanism [22] involves its ability to inhibit nuclear factor kappa B (NF-B), a transcription factor responsible for the transcription and production of multiple pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-), IL-1, and IL-6

Numerous studies suggest that high-dose (often injected) carnitine supplements may improve some or all of these symptoms in patients undergoing a long-term hemodialysis treatment, but the studies have mostly been performed on a small number of patients and have not been double-blind studies

the most abundant carnitine ester) are around 3 to 6 mol/L (8)