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MentholMenthol activates cold receptors (TRPM8) in the skin and nerve endings, producing a cooling sensation

Arch Dermatol Res 296(4):169174

Drug combinations can produce synergy which can be extraordinarily potent making this an intriguing direction

[DOI] [PMC free article] [PubMed] [Google Scholar] 199.Piyathilake C.J., Macaluso M., Hine R.J., Richards E.W., Krumdieck C.L

These data could provide a sound basis to develop a simple, safe, and inexpensive nutritional intervention to improve glutathione production and reduce oxidant damage in aging humans
