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TMAO and the inflammasome NLRP3 The activation of the NLRP3 inflammasome is a critical mediator of TMAO-induced pro-inflammatory effects

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On the one hand, TMAO levels are dynamically changing in human circulation (this physiological concentration range is also controversial) and are strictly regulated by factors such as age, diet, gut microbiota composition, hepatic enzyme activity, as well as liver and kidney function

DHA aids in brain

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Romigi et al