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However, NRF2 was also recently described to promote ferroptosis via increased HO-1 expression, which subsequently resulted in heme degradation and release of labile iron that could promote lipid peroxidation and ferroptosis [313]

In contrast, in vivo animal studies have the advantage of estimating the toxic effects of metal-based NPs in complex physiological environments

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While high cross-validated accuracies for PD diagnosis have been reported for some of the published omics signatures 7,8 , the training and test set sizes used to evaluate the corresponding machine learning (ML) models are often small

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