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The combination group showed significantly higher improvement scores than the dermaroller-only group at baseline and Week 3, with p-values indicating statistically significant differences

The oxidative stress index (OSI) was calculated using the following formula: The spectrophotometric measurement of paraoxonase (PON-1) activity was performed using a commercial PON-1 assay kit (RelAssay Diagnostics, Gaziantep, Turkey)

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This vitamin supplement is widely used to address vitamin B12 deficiencies and support neurological health, providing essential nutrients under medical supervision