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Expression of GPX4 regulates ROS-induced cell death in LCL-K cell Based on the finding that GPX4 overexpression in DLBCL correlated with poor patient prognosis and negatively correlated with intracellular ROS accumulation as determined by 8-OHdG staining, we hypothesized that overexpression induces resistance of tumor cells to ROS-induced cell death

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The antioxidant administered before A induced oxidation occurred decreased protein and lipid oxidation, nitration of proteins, and increased glutathione peroxidase and reductase activity compared to age matched controls [48]

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Addor FAS, Barcaui CB, Gomes EE, Lupi O, Marcon CR, Miot HA

Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria

However, more investigations are needed to improve the effects of polyphenols such as their interaction with other drugs, or synergies with other biological compounds, and also the dosage and bioavailability of polyphenols