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Abstract Dysregulation of lipid metabolic homeostasis is a central pathological feature of metabolic disorders, including obesity and non-alcoholic fatty liver disease

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Gluconeogenesis cannot combine with acetyl CoA Thiolase combines 2 acetyl CoA acetoacetyl CoA HMG-CoA synthase HMG-CoA synthase An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA

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